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Several brain supplements promise to boost cognition, but their efficacy varies. Modalert 200, a prescription cognitive enhancer, is a popular alternative. Modalert 200 affects brain dopamine and other neurotransmitters to increase attention, alertness, and mental clarity. It was originally developed to treat sleep disorders like narcolepsy. Modalert 200 has been shown to improve alertness and mental function, unlike many over-the-counter brain supplements that use untested herbal substances. Responsible drug use improves productivity, decision-making, and learning. Other non-prescription substances including omega-3 fatty acids, ginkgo biloba, and caffeine may boost brain health and cognition. These alternatives are safer for long-term usage but may not have the same dramatic effects as Modalert 200. To ensure safety and appropriateness, check a doctor before using any brain supplement, particularly prescription medicines. Balance supplements with healthy living choices to boost cognition.